Alcoholic liver disease ( ALD) represents a spectrum of liver injury resulting from alcohol use, ranging from hepatic steatosis to more advanced forms including alcoholic hepatitis (AH), alcoholic cirrhosis (AC) , and acute alcoholic hepatitis presenting as acute on chronic liver failure (ACLF ). ALD is a major cause of liver disease worldwide, both on its own and as a co-factor in the progression of chronic viral hepatitis, nonalcoholic fatty […]

This paper presents the results of a study of patients with nonalcoholic steatohepatitis, alcoholic steatohepatitis, and drug-induced liver injury with concomitant colitis and the development of biliary insufficiency that manifests as a significant decrease in the volume of bile acids and bile. In patients with liver injury and concomitant colitis, changes in intestinal microflora were marked. After a combination therapy of this pathology with phosphatidylcholine and glycyrrhizic acid, an improvement […]

Hepatotoxicity is a form of liver cell injury resulting from multitude of causes, including drugs, toxins, herbal and dietary supplements (HDSs), and other agents. The goal of the American Association for the Study of Liver Diseases (AASLD) Hepatotoxicity Special Interest Group (SIG) is to promote and encourage research, education, and awareness regarding human hepatotoxicity (https://www.aasld.org/membership/member-resources/special-interest-groups/hepatotoxicity).

Liver cancer is a major health problem, being the second leading cause of cancer‐related death worldwide,1 with an annual incidence of more than 850,000 new cases globally.[2] Hepatocellular carcinoma (HCC) represents 85% to 90% of all primary liver cancers and occurs mainly in the setting of chronic inflammatory liver diseases.[2] Only 40% to 50% of patients with HCC are diagnosed at early stages (Barcelona Clinic Liver Cancer [BCLC] 0‐A) amenable […]

In the United States, the number of individuals older than 75 years is projected to double to more than 10% of the population by the year 2050,[1] and the question of whether to transplant patients of advanced age has thus become increasingly relevant. In practice, however, this is not a question of whether these patients deserve transplantation any more or less than younger patients. Nor is it a question of […]

Everyone wants to live an active and healthy life and to live as long as possible. The physicians, scientists, biologists, geneticists, biohackers explore information on the diagnosis of aging, longevity of the indicators on the impact of nutrition, genetics, living conditions, as well as the means of influencing the life expectancy. The scientists around of the the world are looking for drugs for longevity. The developments in science and new […]